I have practiced medicine for 24 years, and in that time, I have seen many challenges in the industry. The issues surrounding GLP-1 medications have exposed some of the worst aspects of big pharma. Supply chain issues and rising demand have contributed to the problem. However, it’s also clear that pharmaceutical companies have played a role by shifting toward direct-to-consumer marketing.
What Does the 2025 GLP-1 Medication Shortage Mean for You?
When the FDA declares a drug shortage, compounding pharmacies are allowed to produce versions of the medication. These pharmacies specialize in creating customized medications that are often more affordable. However, once the FDA lifts the shortage designation, compounding pharmacies must stop production. This leaves patients with fewer options—many of which are more expensive.
If you have been using compounded semaglutide or tirzepatide for weight loss, you may now be dealing with shortages or much higher prices. But don’t worry—there are still options available.
What Are Your Options for Continuing Weight Loss Treatment Amid Medication Shortages?
Option 1: Order Directly from the Pharmaceutical Company
- Novo Nordisk and Lilly now offer their medications directly to consumers.
- Prices range from $499/month for Wegovy/Ozempic and $349-$699/month for Mounjaro/Zepbound.
- These medications will be shipped directly to your home for convenience.
Option 2: Lower Your Dose
- Medication costs are often dose-dependent. Reducing your dose can make it more affordable.
- An experienced obesity medicine physician can supplement with additional treatments to maintain appetite control.
Option 3: Consider Alternative Medications
If GLP-1 medications are no longer an option, other medications can be just as effective for weight management:
1. Phentermine
- Suppresses appetite and slightly increases metabolism.
- Available in low-dose versions like Lomaira (8mg) for gradual adjustment.
- Cost: $5-$15 per month.
2. Diethylpropion
- Short-acting appetite suppressant lasting 4-6 hours.
- Ideal for late afternoon or evening cravings.
- Cost: $18-$25 per month.
3. Contrave (Bupropion + Naltrexone)
- Targets both appetite suppression and addiction pathways.
- Requires a gradual increase in dosage.
- Cost: $99 with a coupon, or $500-$615 at full price.
4. Topamax (Topiramate)
- Studied for binge eating disorder (BED).
- Low cost but requires careful titration.
- Cost: $5-$35 per month.
5. Vyvanse (Lisdexamfetamine)
- Originally for ADHD but also FDA-approved for binge eating disorder.
- Once-daily dosage, though insurance coverage varies.
- Cost: $50-$150 per month (generic available).
6. Additional Alternatives
- Saxenda – a once-daily injectable GLP-1.
- Rybelsus – an oral GLP-1 taken daily.
- Naltrexone – a medication used for binge eating disorder and other addictions.
- Chromium – a mineral used for cravings; take three times a day with meals.
- Akkermansia – a supplement used for weight loss that balances the gut flora, making it easier to lose weight.
- Retatrutide peptide – touted for better weight loss than tirzepatide.
- Metformin – used to treat insulin resistance and PCOS; helps decrease appetite by improving insulin resistance.
What Should You Know About the Current Medication Shortages?
Even with efforts to improve supply chains, GLP-1 medications will likely remain difficult to access at consistent prices. You may face:
- Expiring coupons.
- Pharmacy shortages.
- Insurance coverage denials.
Why Expert Guidance Matters
Navigating these challenges is easier with the help of an experienced obesity medicine physician. They can customize your treatment plan to support weight loss while minimizing costs. Even with changing circumstances, the right approach can help keep the scale moving in the right direction.
Updated Medication Pricing
Final Considerations for Managing Weight Loss Amid Medication Shortages
The shortage and cost challenges of GLP-1 medications are unlikely to end soon. However, weight management is about more than just medication. Explore:
- Non-pharmaceutical alternatives such as herbs and supplements.
- Dietary adjustments and behavioral techniques.
- More affordable and accessible medication options as listed above.
- Tweaks to your diet, like adding intermittent fasting or switching to a ketogenic plan.
Injectables are not the only solution! Many patients have successfully lost weight without them. Stay informed, explore your options, and don’t let pharmaceutical hurdles stop your progress.Want to learn more? Follow along on Facebook and Instagram, where I share expert advice and support for your weight loss journey!
